Anyone living in the Pharma engineering world knows that for a state of the art cGMP facility, a modular cleanroom system is the way to go when fitting out graded cleanroom manufacturing spaces and controlled environments. However, if first costs is the driving force, you can achieve this with stick-built if done correctly. In this article, Precis Director of Process Architecture, Mike Brodsky, AIA, NCARB, discusses the pros and cons of Modular vs Stick-built facilities, and guidelines for achieving a stick-built cleanroom design that meets cGMP standards.